The diagnosis of multiple myeloma requires increased numbers of immature abnormal or atypical plasma cells in the bone marrow a monoclonal protein in the serum or urine or characteristic bone lesions the diagnostic workup in a patient with suspected multiple myeloma should include a complete blood count with differential serum chemistries creatinine lactate dehydrogenase and beta2 . Multiple myeloma diagnosis sometimes multiple myeloma is diagnosed when your doctor detects it accidentally during a blood test for some treatment keeping multiple myeloma under control if youre experiencing symptoms treatment can help relieve pain clinical trials explore mayo clinic . The diagnosis and treatment of multiple myeloma has changed dramatically in the past decade the disease definition has been updated to include highly specific biomarkers in addition to established markers of end organ damage the staging system has been revised to combine both measures of tumor burden and disease biology advances in therapy have resulted in a marked improvement in overall . Multiple myeloma accounts for 16 of all cancer cases and approximately 10 of hematologic malignancies in the united states in 2015 an estimated 28850 new cases of multiple myeloma were
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